HH_S1F - Human heavy chain, silent, 1-mer, functional substitution model.
1-mer substitution model of somatic hypermutation based on analysis of silent mutations in functional heavy chain Ig sequences from Homo sapiens.
A 4x4 matrix of nucleotide substitution rates. The rates are normalized, therefore each row sums up to 1.
HS1FDistance in versions of SHazaM prior to 0.1.5.
- Yaari G, et al. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data. Front Immunol. 2013 4(November):358.