HKL_S1F - Human kappa and lambda chain, silent, 1-mer, functional substitution model.
1-mer substitution model of somatic hypermutation based on analysis of silent mutations in functional kappa and lambda light chain Ig sequences from Homo sapiens.
A 4x4 matrix of nucleotide substitution rates. The rates are normalized, therefore each row sums up to 1.
Reported in Table III in Cui et al, 2016.
- Cui A, Di Niro R, Vander Heiden J, Briggs A, Adams K, Gilbert T, O’Connor K, Vigneault F, Shlomchik M and Kleinstein S (2016). A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. The Journal of Immunology, 197(9), 3566-3574.