MK_RS1NF - Mouse kappa chain, replacement and silent, 1-mer, non-functional substitution model.


1-mer substitution model of somatic hypermutation based on analysis of replacement and silent mutations in non-functional kappa light chain Ig sequences from NP-immunized Mus musculus.




A 4x4 matrix of nucleotide substitution rates. The rates are normalized, therefore each row sums up to 1.


MK_RS1NF replaces M1NDistance from versions of SHazaM prior to 0.1.5.


  1. Cui A, Di Niro R, Vander Heiden J, Briggs A, Adams K, Gilbert T, O’Connor K, Vigneault F, Shlomchik M and Kleinstein S (2016). A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data. The Journal of Immunology, 197(9), 3566-3574.

See also

See HH_S1F for the human heavy chain 1-mer substitution model and HKL_S1F for the human light chain 1-mer substitution model.